Download PDF by Petra Seeber, Aryeh Shander(auth.): Basics of Blood Management, Second edition

By Petra Seeber, Aryeh Shander(auth.)

ISBN-10: 0470670703

ISBN-13: 9780470670705

ISBN-10: 1118338073

ISBN-13: 9781118338070

Content material:
Chapter 1 historical past and association of Blood administration (pages 1–8):
Chapter 2 body structure of Anemia and Oxygen delivery (pages 9–20):
Chapter three Anemia remedy I: Erythropoiesis?Stimulating brokers (pages 21–35):
Chapter four Anemia remedy II: Hematinics (pages 36–50):
Chapter five progress elements (pages 51–66):
Chapter 6 Fluid administration (pages 67–80):
Chapter 7 Chemistry of Hemostasis (pages 81–99):
Chapter eight Recombinant Blood items (pages 100–108):
Chapter nine man made Blood (pages 109–123):
Chapter 10 Oxygen treatment (pages 124–138):
Chapter eleven practise of the sufferer for surgical procedure (pages 139–159):
Chapter 12 Iatrogenic Blood Loss (pages 160–172):
Chapter thirteen actual equipment of Hemostasis (pages 173–190):
Chapter 14 Anesthesia—More than snoozing (pages 191–200):
Chapter 15 Use of Autologous Blood (pages 201–211):
Chapter sixteen mobile Salvage (pages 212–228):
Chapter 17 Blood?Derived prescription drugs (pages 229–244):
Chapter 18 Transfusion medication (pages 245–261):
Chapter 19 step-by-step to an geared up Blood administration software (pages 262–284):
Chapter 20 legislations, Ethics, faith, and Blood administration (pages 285–296):

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Additional resources for Basics of Blood Management, Second edition

Example text

In this endocrine function, it originates mainly in the kidneys and is transported by the blood plasma to the target tissues. EPO receptors are distributed throughout the body, including the central nervous system. The heart, retina, vessels, lungs, liver, gastrointestinal tract, ovaries, and uterus also carry EPO receptors. Apart from the kidneys and liver, other tissues are able to produce EPO and EPO-like molecules but do not release EPO into the circulation. The synthesized EPO is used by neighboring cells (paracrine) or by the producing cell itself (autocrine).

These are generic compounds typically produced after the patent rights of the original products have expired. Anticipated reduced costs will hopefully result from the introduction of these chemically produced agents. The biosimilar agents have somewhat different protein structures that may lead to side effects, possibly including antibody formation. However, clinically they should have efficacy similar to the original EPO in enhancing erythropoiesis. rHuEPO requires parenteral application (either intravenously or subcutaneously) to stimulate erythropoiesis.

Hospitalized and especially critically ill patients develop anemia over the course of time. This multifactorial process includes a reduced erythropoietic response due to inflammation and iatrogenic blood loss. rHuEPO is able to alleviate the anemia of critical illness [16] and has been shown to improve outcome. 2 Structure of erythropoietin (EPO) and novel erythropoietin-stimulating protein (NESP; engineered to contain five N-linked carbohydrate chains carrying sialic acid residues). Source: Rizzo et al.

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Basics of Blood Management, Second edition by Petra Seeber, Aryeh Shander(auth.)


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